Article
New insight into the hypercoagulability of Cushing's syndrome.
Neuroendocrinology - 1 Jan 2011
Daidone Viviana, Boscaro Marco, Pontara Elena, Cattini Maria Grazia, Occhi Gianluca, Scaroni Carla, Mantero Franco, Casonato Alessandra
Abstract excerpt
BACKGROUND: Hypercoagulability and a tendency for thromboembolic complications are reported in Cushing's syndrome (CS). The hypercoagulability is due mainly to the cortisol-induced increase in von Willebrand factor (VWF) and factor VIII. This is not a constant feature of CS, however; it depends on particular single nucleotide polymorphism (SNP) haplotypes in the VWF gene promoter: haplotype 1...
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