Article
Genetic association and sequencing of the insulin-like growth factor 1 gene in bipolar affective disorder.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2011
Pereira Ana C Parente, McQuillin Andrew, Puri Vinay, Anjorin Adebayo, Bass Nicholas, Kandaswamy Radhika, Lawrence Jacob, Curtis David, Sklar Pamela, Purcell Shaun M, Gurling Hugh M D
Abstract excerpt
Insulin-like growth factor 1 (IGF1) has been shown to have an important role in brain development and function. Studies of IGF1 administration in rodents have shown that it has an anxiolytic and antidepressant effect. A genome-wide association study (GWAS) of the first University College London (UCL) cohort of 506 bipolar affective disorder subjects and 510 controls was carried out. The exons and flanking regions...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.