Article
Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes.
Nucleic acids research - 1 Jun 2011
Monk David, Arnaud Philippe, Frost Jennifer M, Wood Andrew J, Cowley Michael, Martin-Trujillo Alejandro, Guillaumet-Adkins Amy, Iglesias Platas Isabel, Camprubi Cristina, Bourc'his Deborah, Feil Robert, Moore Gudrun E, Oakey Rebecca J
Abstract excerpt
Imprinted retrotransposed genes share a common genomic organization including a promoter-associated differentially methylated region (DMR) and a position within the intron of a multi-exonic 'host' gene. In the mouse, at least one transcript of the host gene is also subject to genomic imprinting. Human retrogene orthologues are imprinted and we reveal that human host genes are not imprinted. This coincides with...
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