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Article

Do cell junction protein mutations cause an airway phenotype in mice or humans?

American journal of respiratory cell and molecular biology - 1 Aug 2011

Chang Eugene H, Pezzulo Alejandro A, Zabner Joseph

Abstract excerpt

Cell junction proteins connect epithelial cells to each other and to the basement membrane. Genetic mutations of these proteins can cause alterations in some epithelia leading to varied phenotypes such as deafness, renal disease, skin disorders, and cancer. This review examines if genetic mutations in these proteins affect the function of lung airway epithelia. We review cell junction proteins with examples of...

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PMID: 21297078
DOI: 10.1165/rcmb.2010-0498TR
PMCID: PMC3175552

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