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Article

MYB transcriptionally regulates the miR-155 host gene in chronic lymphocytic leukemia

4 Feb 2011

Abstract excerpt

Elevated levels of microRNA miR-155 represent a candidate pathogenic factor in chronic B-lymphocytic leukemia (B-CLL). In this study, we present evidence that MYB (v-myb myeloblastosis viral oncogene homolog) is overexpressed in a subset of B-CLL patients. MYB physically associates with the promoter of miR-155 host gene (MIR155HG, also known as BIC, B-cell integration cluster) and stimulates its transcription....

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PMID: 21296997
DOI: 10.1182/blood-2010-05-285064

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