Article
Replication analysis of SNPs on 9p21.2 and 19p13.3 with amyotrophic lateral sclerosis in East Asians.
Neurobiology of aging - 1 Apr 2011
Iida Aritoshi, Takahashi Atsushi, Deng Min, Zhang Yun, Wang Jing, Atsuta Naoki, Tanaka Fumiaki, Kamei Tetsumasa, Sano Motoki, Oshima Shuichi, Tokuda Torao, Morita Mitsuya, Akimoto Chizuru, Nakajima Masahiro, Kubo Michiaki, Kamatani Naoyuki, Nakano Imaharu, Sobue Gen, Nakamura Yusuke, Fan Dongsheng, Ikegawa Shiro
Abstract excerpt
We performed a replication study of the 2 genetic variants, rs2814707 on 9p21.2 and rs12608932 on 19p13.3 that are recently reported to be most significantly associated with sporadic amyotrophic lateral sclerosis (ALS) in Caucasians. Both rs12608932 and rs2814707 showed no evidence of association in Japanese and Chinese (rs12608932, combined p = 0.58, odds ratio [OR] = 1.03, 95% confidence interval [CI]...
