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Article

Hierarchical delivery of an essential host colonization factor in enteropathogenic Escherichia coli.

The Journal of biological chemistry - 5 Oct 2007

Thomas Nikhil A, Deng Wanyin, Baker Noel, Puente Jose, Finlay B Brett

Abstract excerpt

Many significant bacterial pathogens use a type III secretion system to inject effector proteins into host cells to disrupt specific cellular functions, enabling disease progression. The injection of these effectors into host cells is often dependent on dedicated chaperones within the bacterial cell. In this report, we demonstrate that the enteropathogenic Escherichia coli (EPEC) chaperone CesT interacts with a...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17681945
DOI: 10.1074/jbc.M706019200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hierarchical delivery of an essential host colonization factor in enteropathogenic Escherichia coli.PMID 17681945Read ↗

CesT is a multi‐effector chaperone and recruitment factor required for the efficient type III secretion of both LEE‐ and non‐LEE‐encoded effectors of enteropathogenic Escherichia coliSemantic proximity Read ↗

Tandem tyrosine residues in the EPEC multicargo chaperone CesT support differential type III effector translocation and early host colonizationSemantic proximity Read ↗

Enteropathogenic Escherichia coli translocated intimin receptor, Tir, requires a specific chaperone for stable secretion.Semantic proximity Read ↗

A novel C-terminal region within the multicargo type III secretion chaperone CesT contributes to effector secretion.Semantic proximity Read ↗

Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli.Semantic proximity Read ↗

EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coli.Semantic proximity Read ↗

CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB.Semantic proximity Read ↗

The effector repertoire of enteropathogenic E. coli: ganging up on the host cellSemantic proximity Read ↗

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