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Telomerase-targeted therapies in myeloid malignancies

22 May 2023

Abstract excerpt

Human telomeres are tandem arrays that are predominantly composed of 5'-TTAGGG-3' nucleotide sequences at the terminal ends of chromosomes. These sequences serve 2 primary functions: they preserve genomic integrity by protecting the ends of chromosomes, preventing inappropriate degradation by DNA repair mechanisms, and they prevent loss of genetic information during cellular division. When telomeres shorten to...

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PMID: 37216228
DOI: 10.1182/bloodadvances.2023009903

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