Article
Marrow cell genetic phenotype change induced by human lung cancer cells.
Experimental hematology - 1 Nov 2011
Del Tatto Michael, Ng Thomas, Aliotta Jason M, Colvin Gerald A, Dooner Mark S, Berz David, Dooner Gerri J, Papa Elaine F, Hixson Douglas C, Ramratnam Bharat, Aswad Bassam I, Sears Edmund H, Reagan John, Quesenberry Peter J
Abstract excerpt
Microvesicles have been shown to mediate varieties of intercellular communication. Work in murine species has shown that lung-derived microvesicles can deliver mRNA, transcription factors, and microRNA to marrow cells and alter their phenotype. The present studies evaluated the capacity of excised human lung cancer cells to change the genetic phenotype of human marrow cells. We present the first studies on...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.