Article
Association between PPAR-γ and RXR-α gene polymorphism and metabolic syndrome risk: a case-control study of a Chinese Han population.
Archives of medical research - 1 Apr 2012
Shi Hui, Yu Xiaofang, Li Qian, Ye Xinhua, Gao Yanqin, Ma Jianhua, Cheng Jinluo, Lu Ying, Du Wencong, Du Juan, Ye Qing, Zhao Xu, Zhou Ling
Abstract excerpt
BACKGROUND AND AIMS: Polymorphisms in peroxisome proliferator activated receptor-γ (PPAR-γ) and retinoid X receptor-α (RXR-α) gene may alter metabolic syndrome (MetS) risks by increasing or decreasing the human adiponectin promoter activity in cells. To test this statement, three potentially functional SNPs of PPAR-γ and four SNPs of RXR-α with minor allele frequency (MAF) ≥0.05 in the Chinese Han population were...
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