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Article

FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.

PloS one - 20 Jan 2011

Ewens Kathryn G, Jones Michelle R, Ankener Wendy, Stewart Douglas R, Urbanek Margrit, Dunaif Andrea, Legro Richard S, Chua Angela, Azziz Ricardo, Spielman Richard S, Goodarzi Mark O, Strauss Jerome F

Abstract excerpt

Polycystic ovary syndrome (PCOS) is the leading cause of anovulatory infertility in women. It is also associated with metabolic disturbances that place women at increased risk for obesity and type 2 diabetes. There is strong evidence for familial clustering of PCOS and a genetic predisposition. However, the gene(s) responsible for the PCOS phenotypes have not been elucidated. This two-phase family-based and...

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Source

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Identifiers

PMID: 21283731
DOI: 10.1371/journal.pone.0016390
PMCID: PMC3024473

Genes

FTO
NEGR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome.PMID 21283731Read ↗

Differential Association of FTO Gene variants and Haplotypes with the Susceptibility to Polycystic Ovary Syndrome According To Obesity in Women with PCOS.Semantic proximity Read ↗

BMI-associated alleles do not constitute risk alleles for polycystic ovary syndrome independently of BMI: a case-control study.Semantic proximity Read ↗

Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome.Semantic proximity Read ↗

FTO gene variants are not associated with polycystic ovary syndrome in women from Southern Brazil.Semantic proximity Read ↗

FTOGene Variants Are Associated with PCOS Susceptibility and Hyperandrogenemia in Young Korean WomenSemantic proximity Read ↗

Bidirectional Mendelian randomization to explore the causal relationships between body mass index and polycystic ovary syndromeSemantic proximity Read ↗

Association between fat mass- and obesity-associated (FTO) gene polymorphism and polycystic ovary syndrome: a meta-analysis.Semantic proximity Read ↗

The role of FTO variants in the susceptibility of polycystic ovary syndrome and in vitro fertilization outcomes in Chinese women.Semantic proximity Read ↗

Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS).Semantic proximity Read ↗

Interaction between common variants of FTO and MC4R is associated with risk of PCOS.Semantic proximity Read ↗

Association of common variants of FTO in women with polycystic ovary syndrome.Semantic proximity Read ↗

Association between fat mass and obesity associated (FTO) gene rs9939609 A/T polymorphism and polycystic ovary syndrome: a systematic review and meta-analysis.Semantic proximity Read ↗

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