Article
Intra- and extracellular activities of dicloxacillin and linezolid against a clinical Staphylococcus aureus strain with a small-colony-variant phenotype in an in vitro model of THP-1 macrophages and an in vivo mouse peritonitis model.
Antimicrobial agents and chemotherapy - 1 Apr 2011
Sandberg Anne, Lemaire Sandrine, Van Bambeke Françoise, Tulkens Paul M, Hughes Diarmaid, von Eiff Christof, Frimodt-Møller Niels
Abstract excerpt
The small-colony-variant (SCV) phenotype of Staphylococcus aureus has been associated with difficult-to-treat infections, reduced antimicrobial susceptibility, and intracellular persistence. This study represents a detailed intra- and extracellular investigation of a clinical wild-type (WT) S. aureus strain and its counterpart with an SCV phenotype both in vitro and in vivo, using the THP-1 cell line model and...
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