Article
Impact of the N348I mutation in HIV-1 reverse transcriptase on nonnucleoside reverse transcriptase inhibitor resistance in non-subtype B HIV-1.
Antimicrobial agents and chemotherapy - 1 Apr 2011
McCormick Adele L, Parry Chris M, Crombe Anne, Goodall Ruth L, Gupta Ravindra K, Kaleebu Pontiano, Kityo Cissy, Chirara Michael, Towers Greg J, Pillay Deenan
Abstract excerpt
We investigated the effect of N348I alone and with M184V on nonnucleoside reverse transcriptase inhibitor (NNRTI) drug susceptibility and replicative capacity in B and non-B HIV-1 isolates. N348I reduced the susceptibility to all NNRTI drugs across subtypes. The replication capacity of all viruses in a variety of cell lines was impaired by N348I. Interestingly, the N348I and M184V double mutation compensated for...
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