Article
Common variants in ZNF365 are associated with both mammographic density and breast cancer risk.
Nature genetics - 1 Mar 2011
Lindström Sara, Vachon Celine M, Li Jingmei, Varghese Jajini, Thompson Deborah, Warren Ruth, Brown Judith, Leyland Jean, Audley Tina, Wareham Nicholas J, Loos Ruth J F, Paterson Andrew D, Rommens Johanna, Waggott Darryl, Martin Lisa J, Scott Christopher G, Pankratz V Shane, Hankinson Susan E, Hazra Aditi, Hunter David J, Hopper John L, Southey Melissa C, Chanock Stephen J, Silva Isabel dos Santos, Liu JianJun, Eriksson Louise, Couch Fergus J, Stone Jennifer, Apicella Carmel, Czene Kamila, Kraft Peter, Hall Per, Easton Douglas F, Boyd Norman F, Tamimi Rulla M
Abstract excerpt
High-percent mammographic density adjusted for age and body mass index is one of the strongest risk factors for breast cancer. We conducted a meta analysis of five genome-wide association studies of percent mammographic density and report an association with rs10995190 in ZNF365 (combined P = 9.6 × 10(-10)). Common variants in ZNF365 have also recently been associated with susceptibility to breast cancer.
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