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Article

The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons.

Journal of neurochemistry - 1 Apr 2011

Gkogkas Christos, Wardrope Caroline, Hannah Matthew, Skehel Paul

Abstract excerpt

VAMP/synaptobrevin associated proteins A and B (VAPA and VAPB), are type IV membrane proteins enriched on ER and Golgi membranes. Both VAPA and B interact with cytoplasmic lipid transport proteins and cytoskeletal elements to maintain the structure and composition of ER and Golgi membranes. Truncated forms of both proteins are present in some tissues but the functional significance of this is not clear. In...

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Source

Identifiers

PMID: 21275991
DOI: 10.1111/j.1471-4159.2011.07201.x

Genes

VAPB
VAPA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The ALS8-associated mutant VAPB(P56S) is resistant to proteolysis in neurons.PMID 21275991Read ↗

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Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8).Semantic proximity Read ↗

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A mutation in human VAP-B--MSP domain, present in ALS patients, affects the interaction with other cellular proteins.Semantic proximity Read ↗

Restructured endoplasmic reticulum generated by mutant amyotrophic lateral sclerosis-linked VAPB is cleared by the proteasomeSemantic proximity Read ↗

Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates.Semantic proximity Read ↗

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Neuronal overexpression of human VAPB slows motor impairment and neuromuscular denervation in a mouse model of ALS.Semantic proximity Read ↗

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