Article
Common genetic variation in the 3'-untranslated region of gonadotropin-releasing hormone receptor regulates gene expression in cella and is associated with thyroid function, insulin secretion as well as insulin sensitivity in polycystic ovary syndrome patients.
Human genetics - 1 May 2011
Li Qiaoli, Yang Guizhong, Wang Ying, Zhang Xiaoping, Sang Qing, Wang Huan, Zhao Xinzhi, Xing Qinghe, He Lin, Wang Lei
Abstract excerpt
Gonadotropin-releasing hormone receptor (GNRHR) is a member of the G protein-coupled Ca(2+)-dependent family of receptors. It interacts with GnRH, whose signaling plays an important role in thyroid-stimulating hormone (TSH) secretion and insulin activity. There has been no study on the genetic effect of GNRHR on TSH secretion and insulin action in polycystic ovary syndrome (PCOS). We decided to investigate...
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