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Effect Modification of LHCGR Gene Variant (rs2293275) on Clinico-Biochemical Profile, and Levels of Luteinizing Hormone in Polycystic Ovary Syndrome Patients.

Biochemical genetics - 1 Aug 2023

Makhdoomi Mudassir Jan, Shah Idrees A, Rashid Rabiya, Rashid Aafia, Singh Saurabh, Shah Zaffar Amin, Ganie Mohd Ashraf

Abstract excerpt

Polycystic ovary syndrome (PCOS) is a common multifaceted endocrine disorder among reproductive-aged women. Deranged luteinizing hormone levels and associated downstream signaling cascade mediated by its receptor luteinizing hormone chorionic gonadotropin receptor (LHCGR) are pivotal in the etiopathogenesis of PCOS. Genetic variations in the LHCGR have been associated with PCOS risk. However, the results are...

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PMID: 36633772
DOI: 10.1007/s10528-022-10327-z

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