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Article

Genetic polymorphisms of GnRH and gonadotrophic hormone receptors affect the phenotype of polycystic ovary syndrome.

Human reproduction (Oxford, England) - 1 Aug 2009

Valkenburg O, Uitterlinden A G, Piersma D, Hofman A, Themmen A P N, de Jong F H, Fauser B C J M, Laven J S E

Abstract excerpt

BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex genetic disorder. Multiple functional polymorphisms have been identified in genes that regulate the hypothalamic-pituitary-gonadal (HPG) axis that regulates ovarian function. The present study aims to examine the influence of genetic variants of the HPG-axis on the severity of clinical features of PCOS and disease susceptibility. METHODS: We included 518...

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Source

Identifiers

PMID: 19403562
DOI: 10.1093/humrep/dep113

Genes

FSHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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