Article
B-Raf mutations, microsatellite instability and p53 protein expression in sporadic basal cell carcinomas.
Pathology oncology research : POR - 1 Sept 2011
Stamatelli Angeliki, Saetta Angelica A, Bei Thaleia, Kavantzas Nicolaos, Michalopoulos Nicolaos V, Patsouris Efstratios, Aroni Kiriaki
Abstract excerpt
Basal Cell Carcinoma (BCC) is the most common skin malignancy. Genes related to the Ras/Raf signalling pathway have been implicated in the pathogenesis of skin cancer. The objective of this study was to investigate the presence of B-Raf mutations in sporadic BCCs as well as its correlation with the phenotype of microsatellite instability (MSI), the clinicopathological parameters of the tumours and p53 protein...
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