Article
Cruciferous vegetable supplementation in a controlled diet study alters the serum peptidome in a GSTM1-genotype dependent manner.
Nutrition journal - 27 Jan 2011
Brauer Heather Ann, Libby Tanya E, Mitchell Breeana L, Li Lin, Chen Chu, Randolph Timothy W, Yasui Yutaka Y, Lampe Johanna W, Lampe Paul D
Abstract excerpt
BACKGROUND: Cruciferous vegetable intake is inversely associated with the risk of several cancers. Isothiocyanates (ITC) are hypothesized to be the major bioactive constituents contributing to these cancer-preventive effects. The polymorphic glutathione-S-transferase (GST) gene family encodes several enzymes which catalyze ITC degradation in vivo. METHODS: We utilized high throughput proteomics methods to examine...
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