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Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study.

Carcinogenesis - 1 Dec 2002

Seow Adeline, Yuan Jian-Min, Sun Can-Lan, Van Den Berg David, Lee Hin-Peng, Yu Mimi C

Abstract excerpt

Dietary intake of cruciferous vegetables (Brassica spp.) has been inversely related to colorectal cancer risk, and this has been attributed to their high content of glucosinolate degradation products such as isothiocyanates (ITCs). These compounds act as anticarcinogens by inducing phase II conjugating enzymes, in particular glutathione S-transferases (GSTs). These enzymes also metabolize ITCs, such that the...

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Source

Identifiers

PMID: 12507929
DOI: 10.1093/carcin/23.12.2055

Genes

GSTM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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