Article
Circadian clocks in human red blood cells.
Nature - 27 Jan 2011
O'Neill John S, Reddy Akhilesh B
Abstract excerpt
Circadian (∼24 hour) clocks are fundamentally important for coordinated physiology in organisms as diverse as cyanobacteria and humans. All current models of the molecular circadian clockwork in eukaryotic cells are based on transcription-translation feedback loops. Non-transcriptional mechanisms in the clockwork have been difficult to study in mammalian systems. We circumvented these problems by developing novel...
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