Article
Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice.
PloS one - 22 Feb 2011
Pietropaolo Susanna, Guilleminot Aurélie, Martin Benoît, D'Amato Francesca R, Crusio Wim E
Abstract excerpt
BACKGROUND: No animal models of autism spectrum disorders (ASD) with good construct validity are currently available; using genetic models of pathologies characterized by ASD-like deficits, but with known causes, may be therefore a promising strategy. The Fmr1-KO mouse is an example of this approach, modeling Fragile X syndrome, a well-known genetic disorder presenting ASD symptoms. The Fmr1-KO is available on...
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