The American College of Gastroenterology Emily Couric Lecture—The Adenoma–Carcinoma Sequence Revisited: Has the Era of Genetic Tailoring Finally Arrived?

Abstract excerpt

Colorectal cancer (CRC) remains a common and often lethal disease. The classic adenoma-carcinoma sequence was defined on histologic grounds but over the last 25 years, the molecular basis of this process has been progressively clarified. There are at least three distinct molecular pathways to CRC: the chromosomal instability (CIN) pathway is thought to be largely driven by mutational events in oncogenes and tumor...

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