Article
Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats.
The Journal of physiology - 15 Mar 2011
Lunde Ida G, Anton Siobhan L, Bruusgaard Jo C, Rana Zaheer A, Ellefsen Stian, Gundersen Kristian
Abstract excerpt
Exercise influences muscle phenotype by the specific pattern of action potentials delivered to the muscle, triggering intracellular signalling pathways. PO2 can be reduced by an order of magnitude in working muscle. In humans, carriers of a hyperactive polymorphism of the transcription factor hypoxia inducible factor 1α (HIF-1α) have 50% more fast fibres, and this polymorphism is prevalent among strength...
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