Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Apr 2011

Tang Ximing, Kadara Humam, Behrens Carmen, Liu Diane D, Xiao Yun, Rice David, Gazdar Adi F, Fujimoto Junya, Moran Cesar, Varella-Garcia Marileila, Lee J Jack, Hong Waun Ki, Wistuba Ignacio I

Abstract excerpt

PURPOSE: Emerging evidence suggests that aberrant expression of oncogenes contributes to development of lung malignancy. The thyroid transcription factor 1 (TITF-1) gene functions as a lineage survival gene abnormally expressed in a significant fraction of non-small cell lung cancers (NSCLC), in particular lung adenocarcinomas. EXPERIMENTAL DESIGN: To better characterize TITF-1 abnormality patterns in NSCLC, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Amplification
Share to Oncogenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pulmonary Surfactant-Associated Protein A

Share to Pulmonary Surfactant-Associated Protein B

Share to Pulmonary Surfactant-Associated Protein C

Share to ras Proteins

Share to Thyroid Nuclear Factor 1

Share to Tissue Array Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 21257719
DOI: 10.1158/1078-0432.CCR-10-1412
PMCID: PMC3078948

Genes

EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormalities of the TITF-1 lineage-specific oncogene in NSCLC: implications in lung cancer pathogenesis and prognosis.PMID 21257719Read ↗

Clinical significance of TTF‐1 protein expression and <i>TTF‐1</i> gene amplification in lung adenocarcinomaSemantic proximity Read ↗

Negative Thyroid Transcription Factor 1 Expression Defines an Unfavorable Subgroup of Lung AdenocarcinomasSemantic proximity Read ↗

Thyroid transcription factor-1 expression prevalence and its clinical implications in non-small cell lung cancer: a high-throughput tissue microarray and immunohistochemistry studySemantic proximity Read ↗

Molecular genetic alterations in thyroid transcription factor 1-negative lung adenocarcinoma in cytology specimens: A subset with aggressive behavior and a poor prognosis.Semantic proximity Read ↗

Prognostic impact of TTF-1 expression in patients with stage IV lung adenocarcinomas.Semantic proximity Read ↗

Thyroid transcription factor 1 (TTF-1) negativity as a predictor of unfavorable response to EGFR-TKI therapy in advanced lung adenocarcinoma patients with EGFR mutations.Semantic proximity Read ↗

Thyroid Transcription Factor 1 Is an Independent Prognostic Factor for Patients With Stage I Lung AdenocarcinomaSemantic proximity Read ↗

TTF1 expression in non‐small cell lung carcinoma: association with <i>TTF1</i> gene amplification and improved survivalSemantic proximity Read ↗

The prognostic role of thyroid transcription factor-1 in lung adenocarcinoma.Semantic proximity Read ↗

Genotype-phenotype correlation in Chinese patients with pulmonary mixed type adenocarcinoma: Relationship between histologic subtypes, TITF-1/SP-A expressions and EGFR mutations.Semantic proximity Read ↗

Immunohistochemistry Profile Predicts EGFR Mutation Status in Lung Adenocarcinoma.Semantic proximity Read ↗

Toward personalized medicine of lung cancer: response to nontargeted therapy in invasive pulmonary adenocarcinoma as a function of tumor cell differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.