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Article

Inferring genetic causal effects on survival data with associated endo-phenotypes.

Genetic epidemiology - 1 Feb 2011

Lipman Peter J, Liu Kuang-Yu, Muehlschlegel Jochen Daniel, Body Simon, Lange Christoph

Abstract excerpt

Age-at-onset phenotypes are important traits in genetic association analyses. Often, intermediate phenotypes that are related to the age-at-onset phenotype are also associated with the marker loci that are associated with the age-at-onset phenotype. In order to understand the genetic etiology of the observed associations, statistical methodology is needed to distinguish between a direct genetic effect on the...

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PMID: 21254219
DOI: 10.1002/gepi.20557
PMCID: PMC3125580

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