Article
BCR-ABL1 mutations in patients with imatinib-resistant Philadelphia chromosome-positive leukemia by use of the PCR-Invader assay.
Leukemia research - 1 May 2011
Ono Takaaki, Miyawaki Shuichi, Kimura Fumihiko, Kanamori Heiwa, Ohtake Shigeki, Kitamura Kunio, Fujita Hiroyuki, Sugiura Isamu, Usuki Kensuke, Emi Nobuhiko, Tamaki Shigehisa, Aoyama Yasutaka, Kaya Hiroyasu, Naoe Tomoki, Tadokoro Kenichi, Yamaguchi Toshikazu, Ohno Ryuzo, Ohnishi Kazunori
Abstract excerpt
BCR-ABL1 kinase domain mutations were evaluated in 60 imatinib-resistant patients with Philadelphia-positive (Ph(+)) leukemia using PCR-Invader assay and direct sequencing. In chronic myelogenous leukemia (CML)--chronic phase (CP), 5 had P-loop mutations and 3 had T315I mutations. CML-CP patients with high Sokal score showed significantly higher incidence of mutations. P-loop mutations were associated with higher...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.