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Article

Detection of BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia on imatinib.

Hematology (Amsterdam, Netherlands) - 1 Nov 2013

Chahardouli Bahram, Zaker Farhad, Mousavi Seied Asadollah, Saffari Zeinab, Nadali Fatemeh, Ostadali Mohammadreza, Ghadimi Habibeh, Alimoghaddam Kamran, Ghavamzade Ardeshir, Rostami Shahrbano

Abstract excerpt

BCR-ABL tyrosine kinase domain mutations are the most important factor contributing to imatinib-resistance in patients with chronic myeloid leukemia. We used a semi-nested reverse transcriptase-polymerase chain reaction followed by bidirectional sequencing to detect mutations in a cohort of 110 chronic myeloid leukemia patients. In total, 34 mutations in 19 distinct codons were identified in 32 patients, of which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23676790
DOI: 10.1179/1607845413Y.0000000095

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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