Article
Identification of adult mineralized tissue zebrafish mutants.
Genesis (New York, N.Y. : 2000) - 1 Apr 2011
Andreeva Viktoria, Connolly Michelle H, Stewart-Swift Caitlin, Fraher Daniel, Burt Jeffrey, Cardarelli Justin, Yelick Pamela C
Abstract excerpt
Zebrafish craniofacial, skeletal, and tooth development closely resembles that of higher vertebrates. Our goal is to identify viable adult zebrafish mutants that can be used as models for human mineralized craniofacial, dental, and skeletal system disorders. We used a large-scale forward-genetic chemical N-ethyl-nitroso-urea mutagenesis screen to identify 17 early lethal homozygous recessive mutants with defects...
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