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Article

Reaction mechanism of single subunit NADH-ubiquinone oxidoreductase (Ndi1) from Saccharomyces cerevisiae: evidence for a ternary complex mechanism.

The Journal of biological chemistry - 18 Mar 2011

Yang Yu, Yamashita Tetsuo, Nakamaru-Ogiso Eiko, Hashimoto Takeshi, Murai Masatoshi, Igarashi Junsuke, Miyoshi Hideto, Mori Nozomu, Matsuno-Yagi Akemi, Yagi Takao, Kosaka Hiroaki

Abstract excerpt

The flavoprotein rotenone-insensitive internal NADH-ubiquinone (UQ) oxidoreductase (Ndi1) is a member of the respiratory chain in Saccharomyces cerevisiae. We reported previously that bound UQ in Ndi1 plays a key role in preventing the generation of reactive oxygen species. Here, to elucidate this mechanism, we investigated biochemical properties of Ndi1 and its mutants in which highly conserved amino acid...

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Identifiers

PMID: 21220430
DOI: 10.1074/jbc.M110.175547
PMCID: PMC3059053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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