Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection.

Article

Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1990

Brown C R, McLeod R

Abstract excerpt

To determine roles of MHC class I and II genes in protection against Toxoplasma gondii, H-2 congenic and mutant mice were infected perorally with bradyzoites of T. gondii and brain cysts were enumerated 30 days later. As B10 mice (H-2b) are cyst susceptible and B10.A mice (H-2a) are cyst resistan...

Topics

Animals
Antigens, Differentiation, T-Lymphocyte
CD8 Antigens
Genes, MHC Class I
Genes, MHC Class II
H-2 Antigens
Interferon-gamma
Mice
Mice, Inbred C57BL
Mutation
T-Lymphocytes, Cytotoxic
Toxoplasma
Toxoplasmosis, Animal

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