Article
Polymorphisms in the SULF1 gene are associated with early age of onset and survival of ovarian cancer.
Journal of experimental & clinical cancer research : CR - 7 Jan 2011
Han Chan H, Huang Yu-Jing, Lu Karen H, Liu Zhensheng, Mills Gordon B, Wei Qingyi, Wang Li-E
Abstract excerpt
BACKGROUND: SULF1 (sulfatase 1) selectively removes the 6-O-sulphate group from heparan sulfate, changing the binding sites for extracellular growth factors. SULF1 expression has been reported to be decreased in various cancers, including ovarian cancer. We hypothesized that single nucleotide pol...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
