Article
Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 May 2010
Zhai Rihong, Chen Feng, Liu Geoffrey, Su Li, Kulke Matthew H, Asomaning Kofi, Lin Xihong, Heist Rebecca S, Nishioka Norman S, Sheu Chau-Chyun, Wain John C, Christiani David C
Abstract excerpt
PURPOSE: Apoptosis pathway, gastroesophageal reflux symptoms (reflux), higher body mass index (BMI), and tobacco smoking have been individually associated with esophageal adenocarcinoma (EA) development. However, how multiple factors jointly affect EA risk remains unclear. PATIENTS AND METHODS: In total, 305 patients with EA and 339 age- and sex-matched controls were studied. High-order interactions among reflux,...
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