Article
High-throughput mutation profiling of CTCL samples reveals KRAS and NRAS mutations sensitizing tumors toward inhibition of the RAS/RAF/MEK signaling cascade.
Blood - 24 Feb 2011
Kiessling Michael K, Oberholzer Patrick A, Mondal Chandrani, Karpova Maria B, Zipser Marie C, Lin William M, Girardi Michael, Macconaill Laura E, Kehoe Sarah M, Hatton Charlie, French Lars E, Garraway Levi A, Polier Gernot, Süss Dorothee, Klemke Claus-Detlev, Krammer Peter H, Gülow Karsten, Dummer Reinhard
Abstract excerpt
Cutaneous T-cell lymphomas (CTCLs) are malignancies of skin-homing lymphoid cells, which have so far not been investigated thoroughly for common oncogenic mutations. We screened 90 biopsy specimens from CTCL patients (41 mycosis fungoides, 36 Sézary syndrome, and 13 non-mycosis fungoides/Sézary syndrome CTCL) for somatic mutations using OncoMap technology. We detected oncogenic mutations for the RAS pathway in 4...
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