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Article

Varicella-zoster virus IE63 protein phosphorylation by roscovitine-sensitive cyclin-dependent kinases modulates its cellular localization and activity.

The Journal of biological chemistry - 12 Aug 2005

Habran Lionel, Bontems Sébastien, Di Valentin Emmanuel, Sadzot-Delvaux Catherine, Piette Jacques

Abstract excerpt

During the first stage of Varicella-Zoster virus (VZV) infection, IE63 (immediate early 63 protein) is mostly expressed in the nucleus and also slightly in the cytoplasm, and during latency, IE63 localizes in the cytoplasm quite exclusively. Because phosphorylation is known to regulate various cellular mechanisms, we investigated the impact of phosphorylation by roscovitine-sensitive cyclin-dependent kinase (RSC)...

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Source

Identifiers

PMID: 15955820
DOI: 10.1074/jbc.M503312200

Genes

CDK1
CDK2
CDK5
CDK7
CDK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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