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Article

Microtubule Network Facilitates Nuclear Targeting of Human Cytomegalovirus Capsid

12 Jul 2003

Abstract excerpt

We assessed the requirement of the host cytoskeleton for the intracytosolic transport of incoming human cytomegalovirus (HCMV) capsids. Treatments with microtubule (MT)-depolymerizing drugs nocodazole and colchicine led to a drastic decrease in levels of IE1 antigen, whereas cytochalasin B had no effect on the level of IE1 as determined by Western blot analyses. Sequential treatment including nocodazole washout...

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Share to Advanced biosensing and bioanalysis techniques
Share to Cytomegalovirus and herpesvirus research
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Identifiers

PMID: 12857923
DOI: 10.1128/jvi.77.15.8541-8547.2003

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