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Cell Cycle Arrest in G 2 /M Promotes Early Steps of Infection by Human Immunodeficiency Virus

12 Apr 2005

Abstract excerpt

We have identified four small molecules that boost transduction of cells by human immunodeficiency virus (HIV) and investigated their mechanism of action. These molecules include etoposide and camptothecin, which induce DNA damage by inhibiting religation of cleaved topoisomerase-DNA complexes, taxol, which interferes with the function of microtubules, and aphidicolin, which inhibits DNA polymerases. All four...

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PMID: 15827184
DOI: 10.1128/jvi.79.9.5695-5704.2005

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