Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.

The Journal of clinical investigation - 1 Mar 2018

Kim Geun Hyang, Shi Guojun, Somlo Diane Rm, Haataja Leena, Song Soobin, Long Qiaoming, Nillni Eduardo A, Low Malcolm J, Arvan Peter, Myers Martin G, Qi Ling

Abstract excerpt

Pro-opiomelanocortin (POMC) neurons function as key regulators of metabolism and physiology by releasing prohormone-derived neuropeptides with distinct biological activities. However, our understanding of early events in prohormone maturation in the ER remains incomplete. Highlighting the significance of this gap in knowledge, a single POMC cysteine-to-phenylalanine mutation at position 28 (POMC-C28F) is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endoplasmic Reticulum-Associated Degradation
Share to Hypothalamus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Leptin

Share to Phenylalanine

Share to Pro-Opiomelanocortin

Share to Sulfhydryl Compounds

Share to Ubiquitin

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 29457782
DOI: 10.1172/JCI96420
PMCID: PMC5824855

Genes

POMC

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Hypothalamic ER-associated degradation regulates POMC maturation, feeding, and age-associated obesity.PMID 29457782Read ↗

Deletion of miRNA processing enzyme Dicer in POMC-expressing cells leads to pituitary dysfunction, neurodegeneration and development of obesitySemantic proximity Read ↗

ENPL-1, the Caenorhabditis elegans homolog of GRP94, promotes insulin secretion via regulation of proinsulin processing and maturation.Semantic proximity Read ↗

Evolving questions and paradigm shifts in endoplasmic-reticulum-associated degradation (ERAD).Semantic proximity Read ↗

60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease.Semantic proximity Read ↗

Hypothalamic proopiomelanocortin processing and the regulation of energy balance.Semantic proximity Read ↗

A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding.Semantic proximity Read ↗

Truncating Homozygous Mutation of Carboxypeptidase E (CPE) in a Morbidly Obese Female with Type 2 Diabetes Mellitus, Intellectual Disability and Hypogonadotrophic Hypogonadism.Semantic proximity Read ↗

Transcriptomic Profiling of Developing Melanocortin Neurons Reveals a Role for Prdm12 in Energy BalanceSemantic proximity Read ↗

The Prader-Willi syndrome proteins MAGEL2 and necdin regulate leptin receptor cell surface abundance through ubiquitination pathwaysSemantic proximity Read ↗

PGRMC1 acts as a size-selective cargo receptor to drive ER-phagic clearance of mutant prohormones.Semantic proximity Read ↗

Peptide hormone precursor processing: getting sorted?Semantic proximity Read ↗

Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-lossSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.