Article
Reduced NR4A gene dosage leads to mixed myelodysplastic/myeloproliferative neoplasms in mice.
Blood - 3 Mar 2011
Ramirez-Herrick Ashley M, Mullican Shannon E, Sheehan Andrea M, Conneely Orla M
Abstract excerpt
The NR4A subfamily of nuclear receptors (NR4A1, NR4A2, and NR4A3) function as transcription factors that transduce diverse extracellular signals into altered gene transcription to coordinate apoptosis, proliferation, cell cycle arrest, and DNA repair. We previously discovered that 2 of these rece...
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