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Article

Polymorphisms in an intronic region of the myocilin gene associated with primary open-angle glaucoma--a possible role for alternate splicing.

Molecular vision - 29 Dec 2010

Pandaranayaka P J Eswari, Prasanthi N, Kannabiran N, Rangachari K, Dhivya M, Krishnadas Subbiah R, Sundaresan P, Krishnaswamy S

Abstract excerpt

PURPOSE: To examine the possible role of alternate splicing leading to aggregation of myocilin in primary open-angle glaucoma. METHODS: Several single nucleotide variations found in the myocilin (MYOC) genomic region were collected and examined for their possible role in causing splice-site alterations. A model for myocilin built using a knowledge-based consensus method was used to map the altered protein...

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Source

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Identifiers

PMID: 21203411
PMCID: PMC3013065

Genes

MYOC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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