Article
Evaluation and understanding of myocilin mutations in Indian primary open angle glaucoma patients.
Molecular vision - 14 Nov 2003
Kanagavalli Janakaraj, Krishnadas Subbaiah Ramasamy, Pandaranayaka Eswari, Krishnaswamy Sankaran, Sundaresan Periasamy
Abstract excerpt
PURPOSE: To screen for mutations in the MYOC gene of patients with Primary Open Angle Glaucoma (POAG) in India and to better understand the mutations using a possible model of myocilin. METHODS: We analyzed DNA for mutations in 107 subjects with POAG and 90 normal control subjects. The exonic sequences of the MYOC gene from all subjects were amplified by Polymerase Chain Reaction (PCR). We carried out Single...
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