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Article

Genetic polymorphisms and obesity influence estradiol decline during the menopause.

Clinical endocrinology - 1 May 2011

Sowers Maryfran R, Randolph John F, Zheng Huiyong, Jannausch Mary, McConnell Daniel, Kardia Sharon R, Crandall Carolyn J, Nan Bin

Abstract excerpt

OBJECTIVES: Obesity and genetic variation in aromatase and type 1 17-β hydroxysteroid dehydrogenase (HSD) could influence the E2 trajectory of decline during the menopause transition. DESIGN AND PARTICIPANTS: E2 trajectories during the menopause transition (phenotype) were identified using 5934 data points acquired annually from 681 women in Study of Women's Health across the Nation (SWAN), a multiethnic study of...

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Identifiers

PMID: 21198743
DOI: 10.1111/j.1365-2265.2010.03968.x
PMCID: PMC3357071

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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