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Article

Relaxed complex scheme suggests novel inhibitors for the lyase activity of DNA polymerase beta.

Journal of molecular graphics & modelling - 1 Feb 2011

Barakat Khaled, Tuszynski Jack

Abstract excerpt

DNA polymerase beta (pol β), the error-prone polymerase of base excision repair, plays a significant role in chemotherapeutic agent resistance. Its over expression reduces the efficacy of anticancer drug therapies including ionizing radiation, bleomycin, monofunctional alkylating agents and cisplatin. Small-scale studies on different types of cancer showed that pol β is mutated in approximately 30% of tumors....

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Identifiers

PMID: 21194999
DOI: 10.1016/j.jmgm.2010.12.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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