Article
Predictive role of polymorphisms in interleukin-5 receptor alpha-subunit, lipoprotein lipase, integrin A2 and nitric oxide synthase genes on ischemic stroke in type 2 diabetes--an 8-year prospective cohort analysis of 1327 Chinese patients.
Atherosclerosis - 1 Mar 2011
Luk Andrea O Y, Wang Ying, Ma Ronald C W, Tam Claudia H T, Ng Maggie C Y, Lam Vincent, Yang Xilin, Baum Larry, Tong Peter C Y, Chan Juliana C N, So Wing-Yee
Abstract excerpt
OBJECTIVE: Ischemic stroke is prevalent in type 2 diabetes and may be due to metabolic, vascular and inflammatory factors. Genetic variants implicated in these pathways may have joint effects on stroke risk. In this proof-of-concept study, we examined gene-gene interactions on risk of incident ischemic stroke in an 8-year prospective cohort of Chinese type 2 diabetic patients. METHODS: Seventy-seven single...
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