Article
Combined effect of inflammatory gene polymorphisms and the risk of ischemic stroke in a prospective cohort of subjects with type 2 diabetes: a Go-DARTS study.
Diabetes - 1 Nov 2010
Palmer Colin N A, Kimber Charlotte H, Doney Alex S F, Proia Anna S, Morris Andrew D, Gaetani Eleonora, Quarta Miriam, Smith Roy C, Pola Roberto
Abstract excerpt
OBJECTIVE: We have previously observed that genetic profiles determined by the combination of five functionally significant single nucleotide polymorphisms (SNPs) (rs1800795, rs5498, rs5361, rs1024611, and rs679620) of genes encoding prototypical inflammatory molecules are associated with history of ischemic stroke. Here we tested the ability of this multigenic model to predict stroke risk in a large...