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Article

Dimeric 2G12 as a Potent Protection against HIV-1

16 Dec 2010

Abstract excerpt

We previously showed that broadly neutralizing anti-HIV-1 antibody 2G12 (human IgG1) naturally forms dimers that are more potent than monomeric 2G12 in in vitro neutralization of various strains of HIV-1. In this study, we have investigated the protective effects of monomeric versus dimeric 2G12 against HIV-1 infection in vivo using a humanized mouse model. Our results showed that passively transferred, purified...

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PMID: 21187894
DOI: 10.1371/journal.ppat.1001225

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