5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer.

doi:10.1053/j.gastro.2010.12.035

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Article

5-Fluorouracil adjuvant chemotherapy does not increase survival in patients with CpG island methylator phenotype colorectal cancer.

Gastroenterology - 1 Apr 2011

Jover Rodrigo, Nguyen Thuy-Phuong, Pérez-Carbonell Lucía, Zapater Pedro, Payá Artemio, Alenda Cristina, Rojas Estefanía, Cubiella Joaquín, Balaguer Francesc, Morillas Juan D, Clofent Juan, Bujanda Luis, Reñé Josep M, Bessa Xavier, Xicola Rosa M, Nicolás-Pérez David, Castells Antoni, Andreu Montserrat, Llor Xavier, Boland C Richard, Goel Ajay

Abstract excerpt

BACKGROUND & AIMS: 5-Fluorouracil (5-FU)-based adjuvant chemotherapy does not increase survival times of patients with colorectal tumors with microsatellite instability. We determined the response of patients with colorectal tumors with the CpG island methylator phenotype (CIMP) to 5-FU-based therapy. METHODS: We analyzed a population-based cohort of 302 patients with colorectal cancer (CRC) for a median...

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Identifiers

PMID: 21185836
DOI: 10.1053/j.gastro.2010.12.035
PMCID: PMC3073650

Genes

MLH1
NEUROG1
RUNX3
SOCS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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