Article
Structural alterations in the Bacillus subtilis Spo0A regulatory protein which suppress mutations at several spo0 loci.
Journal of bacteriology - 1 Sept 1990
Spiegelman G, Van Hoy B, Perego M, Day J, Trach K, Hoch J A
Abstract excerpt
Secondary site mutations that restore sporulation to sporulation-defective spo0F or spo0B deletion mutants were found to reside in the spo0A gene. Sequence analysis of 23 such sof mutants showed that the sof mutations fell into six classes of missense codon changes, primarily in the conserved amino-terminal domain of the response regulator Spo0A protein. Changes were observed in codons 12, 14, 60, 92, and 121....
Topics
- Amino Acid Sequence
- Bacillus subtilis
- Bacterial Proteins
- Base Sequence
- Codon
- Genotype
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Phenotype
- Restriction Mapping