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Article

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.

Cancer letters - 28 Oct 2003

Lipton Lara, Fleischmann Christina, Sieber Oliver M, Thomas Huw J W, Hodgson Shirley V, Tomlinson Ian P M, Houlston Richard S

Abstract excerpt

Aneuploidy is a characteristic of a subset of colorectal tumours. CHEK2 (also known as CHK2) is one of the cell cycle checkpoint genes coding for a family of proteins that sense damage in eukaryotic cells. Germline variation in CHEK2 has recently been shown to confer cancer susceptibility. Heterozygous mutations have been identified in patients with TP53-negative Li-Fraumeni syndrome. Furthermore, the CHEK2...

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Source

Identifiers

PMID: 14568168
DOI: 10.1016/s0304-3835(03)00391-4

Genes

CHEK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contribution of the CHEK2 1100delC variant to risk of multiple colorectal adenoma and carcinoma.PMID 14568168Read ↗

Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility.Semantic proximity Read ↗

CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.Semantic proximity Read ↗

Colorectal cancer and the CHEK2 1100delC mutation.Semantic proximity Read ↗

CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer.Semantic proximity Read ↗

CHEK2*1100delC and susceptibility to breast cancer: a collaborative analysis involving 10,860 breast cancer cases and 9,065 controls from 10 studies.Semantic proximity Read ↗

Low-penetrance susceptibility to breast cancer due to CHEK2(*)1100delC in noncarriers of BRCA1 or BRCA2 mutations.Semantic proximity Read ↗

CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.Semantic proximity Read ↗

The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype.Semantic proximity Read ↗

A multicenter study of cancer incidence in CHEK2 1100delC mutation carriers.Semantic proximity Read ↗

Variants in CHEK2 other than 1100delC do not make a major contribution to breast cancer susceptibility.Semantic proximity Read ↗

Absence of the CHEK2 c.1100delC mutation in familial breast and ovarian cancer in Colombia: a case-control studySemantic proximity Read ↗

Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype.Semantic proximity Read ↗

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